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Benefits & Side Effects (Human trial framing) What trials measured (examples): Functional outcomes (e.g., 6minute walk test) Muscle performance measures Safety/tolerability and followup monitoring Because this is gene transfer, safety considerations are evaluated differently than for shortacting peptides

CJC-1295 DAC 5 mg vial: the reconstitution math Concentration is a division problem, and it is the only calculation that matters: Concentration = total mass in vial volume of diluent added For a 5 mg vial with 2.0 mL of bacteriostatic water: 5 mg 2.0 mL = 2.5 mg/mL 2.5 mg/mL 1,000 = 2,500 mcg/mL A U-100 insulin syringe is graduated so that 100 units = 1.0 mL , therefore 1 unit = 0.01 mL 2,500 mcg/mL 0.01 mL = 25 mcg per unit Every dose is then dose 25: Sanity-check the extremes

Following treatment, the treated area swells and remains slightly tender for a week or two

mutans and preventing biofilm formation over time