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The notable increase in Cx32 level in hepatocytes of hepsin / mice, along with our previous work establishing hepsin as a regulator of the cellular abundance of hepatic GJ proteins (Hsu et al

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This is achieved through activation of the GDNF/PI3K/AKT axis, resulting in improved neurological function and a significant reduction in key inflammatory mediators such as IL-6, IL-8, and TNF (Xu et al., 2023)

doi: 10.3389/fnut.2026.1762061 Received 06 December 2025 Revised 11 February 2026 Accepted 18 February 2026 Published 12 March 2026 Volume 13 - 2026 Edited by Amanda N