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As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

PMID: 14990858

If storage was optimal, many peptides retain significant potency past nominal expiration dates

However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements