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Importantly, IDH-1/2 mutations pose an important anti-cancer strategy for hard-to-treat cancer types, these mutations occurring in ~ 7080% of lower-grade gliomas and the majority of secondary glioblastomas and in up to 20% of patients with AML [261, 262]

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TP53 can upregulate the arachidonate 12-lipoxygenase12 (ALOX12) to suppress the growth of tumor cells through triggering ferroptosis [72]

( 5 Conclusions This study demonstrates that parenteral supplementation with a combination of trace minerals and vitamins during the transition period significantly enhances mammary gland immune function, antioxidant capacity, and colostrum and milk quality in dairy cows