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Both familial (fALS, 510% of cases) and sporadic (sALS) forms show similar clinical and pathological features, with overlapping cognitive and behavioral changes, particularly frontotemporal-like symptoms, as well as progressive bulbar and limb motor dysfunction

Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy-a double-blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynakologische Onkologoie (AGO) Ovarian Cancer Study Group

The reactive species oxidize the different types of amino acids present in the protein and result in the generation of the protein-protein cross linkage which further results in the denaturation, loss of protein functioning, loss of transport protein and receptor functioning, and loss of enzymatic activity