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Furthermore, future studies should focus on the establishment of isogenic models incorporating human induced pluripotent stem cells (iPSCs) to minimize allogenic effects 72

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Other studies reported that TMAO increased the expression of CD36 and the formation of foam cells induced by ox-LDL, which could be reduced by siRNA-mediated knockdown of CD36 as well as inhibitors of MAPK (SB230580) and JNK (SP600125)

Eventually, 18 studies meeting the criteria were included in the review 14,15,16,17,18,19,20,31,32,33,34,35,36,37,38,39,40,41 : 12 from the primary database search 15,16,17,20,31,32,33,34,35,36,37,39 , five from Google Scholar 14,18,19,38,41 , and one from a reference list 40 (Fig