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These differences could explain, at least in part, some inconsistencies found among various studies, attributable to the different strains used

The MTHFR gene has been found to have 15 rare variants that are linked to severe enzyme deficit and one common mutation, C677T, that is linked to a lesser enzyme deficit, according to research by Goyette et al

Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy

Nonetheless, it will be necessary to examine the influence of comorbid conditions of ASD on neurometabolite status in future studies with larger sample sizes