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Physiol 1989, 414, 5571

Overall, our data indicate that the addition of disulfiram to chemotherapies might allow for the use of lower doses of conventional chemotherapeutic agents to achieve similar leukemia cell killing efficacy, but that effects are variable across leukemia subtypes and thus careful further preclinical evaluation is needed to identify markers that can predict response to these drug combinations

Through these mechanisms, even relatively low levels of active compounds can generate a fine-tuned yet coordinated regulation of critical signaling pathways such as Nrf2, NF-B, and apoptosis ultimately producing a pronounced and clinically meaningful physiological effect [52]

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