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Unlike enzymatic reactions, which are precisely controlled by respective enzymes, nonenzymatic processes are rather unspecific and occur spontaneously

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Due to their short diffusion lengths and rapid scavenging, these radicals exert their effects within nanometer-to-submicrometer microdomains, making receptor-proximal membranes and specific enzyme complexes privileged initial targets [101103] (Fig

In addition, azelaic acid, metronidazole and sulfacetamide sodium/sulfur are long-established topical therapies available in a variety of formulations, including creams, gels and cleansers