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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B Proc Natl Acad Sci USA 1994 91 : 62886292 Belich MP, Salmeron A, Johnston LH, Ley SC

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Conclusion While preliminary findings highlight the promise of PRP and PRGF as emerging, plasma-based approaches in male reproductive medicine, further research is essential to standardize protocols, evaluate long-term efficacy and safety, and elucidate underlying molecular mechanisms before these therapies can be safely and effectively translated into routine clinical practice