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Taken together, these studies suggest that inducing ferroptosis may serve as promising strategy for treating HCC

Among these factors, the dynamic balance of iron and the abnormality of lipid peroxidation are the most important to induce ferroptosis, while the functional state of System X c and the activity level of GPX4 are the key pathways to regulate ferroptosis

Article contents Abstract References Abstract Glutathione is a key intracellular antioxidant involved in redox balance, detoxification and immune support

Autophagy is an intracellular waste degradation pathway that is activated in response to cellular stress and usually mediates protective rather than cytotoxic effects (Galluzzi et al., 2018)