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Retrieved from Hunt, A., Harrington, D., & Robinson, S

Obesity trials didnt move into Phase III because efficacy signals werent strong enough at the doses tested, but the safety data generated is still useful for characterising the peptides tolerability profile in preclinical research planning

It maintains effectiveness over extended use

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)