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Notably, ChiE also contains residues (H224, C227, D228) arranged in a configuration resembling a catalytic triad (Fig

229 In osteoporosis, MSCs tend to favor adipogenic differentiation, which reduces bone formation and increases fat accumulation within the bone marrow, thereby exacerbating bone loss and increasing the risk of fractures

This paradoxical result, where mice eat more but weigh less on a low methionine diet, was also seen in an independent study of male mice of a genetically heterogeneous background ( Not all mouse studies of low methionine resulted in longer life though

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