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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

Uploading to ClinicalTrials.gov has become easier Per NIH posting dated March 7, 2019: To make registration easier, eRA Human Subjects System (HSS) has a new feature that will allow applications and recipients to export study record entries as an XML file that are included in both systems directly into clinicaltrials.gov

In fact, some preclinical studies even show a protective effect of NAD+ on certain cancer conditions

Kerk, S