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Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

Afferent fibers, which constitute 80% of vagal nerve fibers, transmit mechanical, chemical, and immune signals from the gut to the CNS, whereas efferent fibers (20%) convey central commands to the gut, modulating digestive function and immune responses (Bonaz et al., 2018)

These differences highlight the need for tailored therapeutic strategies, EHS may benefit from early anti-pyroptotic/anti-necroptotic agents, while CHS requires prioritized gut barrier protection and anti-apoptotic interventions