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OPs affect cell viability, 72 and their induced developmental neurotoxicity can be modeled in vitro using RNA-seq to mimic human neurodevelopmental processes, which include proliferation of neural progenitor cells, neuronal and neuroglial differentiation, neurite extension, synaptogenesis, and synaptic transmission, the details of which need to be refined

In particular, NMDAR1 expression was found in tissue sections of prostate, breast, and colon cancers, and has been proven to be functional in tumor-derived cell lines stimulating cell proliferation (128)

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It is not intended to serve as a comprehensive account of all available models, but rather to offer a general perspective on the principal systems currently utilized in the field