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CB-839, a GLS inhibitor that blocks the conversion of glutamine into glutamate, reduced the production of R-2-HG in AML cell lines and patient tissues harboring IDH1/2 mutations 123

10.1046/j.1471-4159.1995.64051965.x J

Although the thyroid gland is not the organ that has the most significant overall amount of Se in the human body, it does have the highest concentration of Se among all endocrine organs and, in fact, among all tissues regarding the amount of Se that it contains per gram [9]

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