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Beneficial species within it, such as butyrate-producing Clostridium cluster XIVa and IV, which are also involved in bile acid metabolism, are typically reduced in abundance in ALD mice [119]

**Pernicious Anemia:** Management of pernicious anemia, a condition characterized by the inability to absorb vitamin B12 from the gastrointestinal tract

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The methionine cycle is responsible for the production of the universal methyl donor S-adenosylmethionine (SAM), which is used in a variety of methyl transfer reactions