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doi: 10.1158/1078-0432.CCR-04-2159

Discussion ME/CFS, GWS, and FM are three chronic conditions presenting with overlapping symptoms, which lack definitive diagnostic tests and effective pharmacological treatments

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In ME/CFS elevated plasma tryptophan levels may enhance the conversion of tryptophan to 5-hydroxytryptophan in the brain, potentially leading to central fatigue, a core symptom of ME/CFS (Castell et al., 2015)