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A study by Zhu et al (136) identified restoring RIPK3 expression to reverse R-2-hydroxyglutarate-induced necroptosis in isocitrate dehydrogenase-mutant AML cells as a potential therapeutic strategy for patients with AML

This can be from being outdoors and in the heat too long on a hot day, and there are reports of problems from sauna or hot steam bath exposure

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There have been reports of corneal clouding or edema following ocular surgery in which BSS PLUS solution was used as irrigating solution