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Cortisol production may become dysregulated in adrenal fatigue, either too high or too low, depending on the stage

Selenium deficiency impairs the glutathione antioxidant system even when glutathione levels are adequate [26]

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Additionally, mRNA expression of iron response element binding protein 2, encodes a master regulator of iron metabolism), and CS (citrate synthase, regulating the mitochondrial fatty acid metabolism) was upregulated in both models, while ACSF2 ((acyl-CoA synthetase family member 2, regulating the mitochondrial fatty acid metabolism) was upregulated only in APPswe/PS1dE9 mice