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(2017) revealed that oral administration of Lactobacillus pentosus GMNL-77, a potential probiotic strain, significantly decreased erythaematous scaling lesions in imiquimod-treated mice with epidermal hyperplasia and psoriasis-like skin inflammation, with decreased tumor necrosis factor-alpha (TNF-), interleukin (IL)-6, and IL-23/IL-17A axis-associated cytokine (IL-23, IL-17A/F, and IL-22) levels in the skin and reduced IL-17- and IL-22-producing CD4+ T cells in the spleen

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The PCA score plots showed no obvious separations among the groups at varying time points (Figure 6A)