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Moreover, KRAS G12D extinction also downregulates several rate-limiting glycolytic enzymes like HK1, hexokinase 2 (HK2), PFKl and lactate dehydrogenase A (LDHA), while decreasing the glucose uptake and lactate production in pancreatic cancer

Moreover, SNPs affecting MAP3K1 turned out to negatively influence the OS of NSCLC patients treated with platinum derivatives plus a taxane, whereas SNPs in the v-raf-1 murine leukemia viral oncogene homolog 1 ( RAF1 ) had an opposite effect on the OS of this patient subgroup

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Designing probes that can produce different reaction products or bind specifically to GSH rather than Cys and Hcy can help improve specificity