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Unlike non-replicating mRNA, SAM contains two ORFs: one that encodes the target antigen and another that encodes the viral replication machinery, which facilitates prolonged RNA amplification within cells ( The main challenges in developing mRNA vaccines revolve around their molecular design and the efficiency of their delivery in vivo

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The gut-skin axis highlights how imbalances in the microbiome can trigger inflammation, potentially worsening autoimmune skin diseases like vitiligo

Potential risks include changes in growth hormones, abnormal tissue growth, or interference with Tissue Regeneration pathways