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n 25) between the postsynaptic marker PSD-95 and the postsynaptic spines suggest that the newly formed spines have a functional postsynaptic element

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A literature review published in 1992 reports hepatotoxicity in six patients from unmodified niacin, two patients from sustained release and in 10 patients after changing from unmodified to time-release preparations, likely due to ingesting time-release niacin at doses well above the usual therapeutic doses [12]