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Finally, axitinib combined with cisplatin and gemcitabine [166] and also bevacizumab plus paclitaxel and carboplatin [163] induced significant anti-tumor effect in NSCLC patients, as documented by improved OS and PFS

Folate is converted to its active form (tetrahydrofolate) in the body, and this compound is a carrier of one-carbon units necessary for synthesizing purines and pyrimidines (nucleotides), which are the building blocks of DNA

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