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2022), abemaciclib treatment instigated a significant increment in the rate of apoptosis by quelling CDK4/6, the overexpressing caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 levels, and downregulating the PI3K/AKT/mTOR pathway in MCF-7 and MDA-MB-231 cell lines

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However, when NADPH levels fall, the inhibition is relieved, the pathway is reactivated, and both NADPH and ribose 5-phosphate are synthesized

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