Neuroinflammation and ferroptosis resulting from cerebrovascular injury can be attenuated by modulating the microglial phenotype
Oligo sequences for competition library: Human SLC25A40 sg1 F: caccGGTTGGATTTCCCTTTGGAG, sg1 R: aaacCTCCAAAGGGAAATCCAACC, sg5 F: caccgAAGAGGGAGGCAACAAACTA, sg5 R: aaacTAGTTTGTTGCCTCCCTCTTc, sg6 F: caccgAAGAAGCCAGGAAATTTCCA, sg6 R: aaacTGGAAATTTCCTGGCTTCTTc, sg7 F: caccGGTACATCTCTAAGAACAGT, sg7 R: aaacACTGTTCTTAGAGATGTACC, sg8 F: caccgCTATGTGTCTGTGAAGAGGG, sg8 R: aaacCCCTCTTCACAGACACATAGc, Human TXNRD2 sg2 F: caccgTAAACCACTGGAGTTCACGG, sg2 R: aaacCCGTGAACTCCAGTGGTTTAc, sg3 F: caccGATTAGGAGGGCGCTTCCGG, sg3 R: aaacCCGGAAGCGCCCTCCTAATC, sg6 F: caccgCAAGAAGCTGATGCACCAGG, sg6 R: aaacCCTGGTGCATCAGCTTCTTGc, sg7 F: caccGCACTACCTGGTCGAAGCCG, sg7 R: aaacCGGCTTCGACCAGGTAGTGC, sg8 F: caccGGAGGACAGCACCACCGGCA, sg8 R: aaacTGCCGGTGGTGCTGTCCTCC, Control sg5 F: GCGGATTAGAGGTAATGCGG, sg5 R: CCGCATTACCTCTAATCCGC, sg6 F: GGAGCCATGGTAGAGCGTAT, sg6 R: ATACGCTCTACCATGGCTCC, sg11 F: GGCGCTCGATTAAGACTCAG, sg11 R: CTGAGTCTTAATCGAGCGCC, sg12 F: GTTACGCGTGCTGTCGCTTC, sg12 R: GAAGCGACAGCACGCGTAAC, sg13 F: GTTCCTTCTGCAGGCACGCT, sg13 R: AGCGTGCCTGCAGAAGGAAC Analysis of transcriptome-wide association studies (TWAS) data We analyzed transcriptome-wide association studies (TWAS) results on 4,000 traits for SLC25A39 in the UK Biobank 12 (n=361,194) using the summary-statistics-based, joint-tissue PrediXcan 51,52
Autophagy 15(11):18601881 Tao W, Hu Y, Chen Z, Dai Y, Hu Y, Qi M (2021) Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway
Noto D, Miyake S (2020) Gut dysbiosis and multiple sclerosis
