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Functionally, this anti-inflammatory effect is associated with reversing the inflammation-induced inhibition of the drug-metabolizing enzyme CYP3A, restoring its expression and activity ( In the context of metabolic disease-related liver injury, the anti-inflammatory mechanism of silybin-loaded liposomes (SLB) in a rat model of type 2 diabetes combined with NAFLD primarily centers on the activation of the AMPK pathway, which in turn dually inhibits metabolic disorders and pro-fibrotic signals

It plays a crucial role in immune function, detoxification capacity, and protection against oxidative stress

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doi: 10.3389/fmicb.2018.02496 76