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doi: 10.3168/jds.s0022-0302(98)75612-7 206 MambulaS

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Several animal toxicity studies showed that inflammatory reactions are initiated by the production of interleukin-1 beta (IL-1), interleukin-6 (IL-6), cyclooxygenases (1 and 2) (COX-1, COX-2), and tumor necrosis factor- (TNF-), causing systemic inflammation []