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Accordingly, efforts to improve drug solubility, control release, optimize activity, and adjust pharmacokinetic (PK) properties constitute the primary directions of research in the delivery of small molecule drugs [44]

Roalf DR, Sydnor VJ, Woods M, Wolk DA, Scott JC, Reddy R, et al

J Hepatol 1999;31:92938

The PerR transcription factor is triggered not by oxidation of a sensory thiol but by the oxidation of a prosthetic iron atom, in a Fenton-type reactionan event that seems likely to be H 2 O 2 -specific (Lee and Helmann, 2006)