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This is because folate supplementation may improve symptoms to the point that the B12 deficiency is not detected in tests, and therefore is not treated

The aberrant accumulation of A and hyperphosphorylated Tau proteins on mitochondria results in mitochondrial respiratory chain complex I activity, impaired mitochondrial membrane potential (MMP), and massive production of reactive oxygen species (ROS), which in turn affects mitochondrial function ( A number of studies have demonstrated that there are extensive mitochondrial abnormalities in the brains of AD patients and animal models (Swerdlow, 2018)

Vitamin B12 is available in oral supplements the highest doses comes from those supplements which only contain vitamin B12 rather than medicines which combine it with other B-complex vitamins or other minerals and supplements (e.g