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Natural compounds evaluated in these models have demonstrated promising results across key pathological pathways, including, reduction of oxidative stress, inhibition of AChE, modulation of inflammatory pathways, preservation of blood-brain barrier integrity, enhancement of spatial and memory-related behaviors

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[21] When treated with cyanocobalamin, patients with Leber's disease may develop serious optic atrophy, possibly leading to blindness, based on few case reports

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity