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Enzyme-linked immunosorbent assay kits were used to determine the levels of pro-inflammatory cytokines, specifically TNF- and IL-6, in cell culture supernatants

doi: 10.1016/j.ibmb.2019.04.005 11 BajgarAKucerovaKJonatovaLTomcalaASchneedorferovaIOkrouhlikJet al

Recent reports have shown that the shear-induced opening of endothelial Piezo1 channels activates the calcium-dependent protease calpain (Li et al., 2014), which in turn cleaves talin (a protein that links membrane integrins to the actin cytoskeleton) to alter integrin-mediated cell adhesion (McHugh et al., 2010)

These plaques are often very itchy and sometimes painful