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10.1016/j.jchemneu.2017.07.002 J

We replaced the complex equations of enzyme-mediated fluxes of the reduced model (Figure 2A) with simple mass action kinetics in the stylized model (Figure 2B)

These results were consistent with previous findings and highlighted the significance of N-myristylation of FSP1, which could target to the plasma membrane, induce NADH-dependent reduction of CoQ, and finally suppresses lipid peroxidation, the hallmark of ferroptosis