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Upregulation of HO-1 with cobalt metalloporphyrin protoporphyrin IX (CoPP) in hRSV-infected mice significantly reduced disease-related body weight loss and induced an upregulation of IFN-/ in the lungs, indicating that HO-1 plays an important role in the development of the antiviral type I IFN response in the airways (106)

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Increased VEGF increased ocular permeability and neovascularization and accelerated the development of diabetic retinopathy [110]

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Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift

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also reported 84.4% and 42.8% OS rates of standard-risk and high-risk groups, respectively [22]

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