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Why Chronic Pain Persists Despite Medication When pain becomes chronic, the issue is rarely a lack of stronger medication

Recent research highlights the significant roles of nutritional deficiencies (Markoulli et al., 2023), inflammation (Wu et al., 2024), and oxidative stress (Li et al., 2022a) in DEDs pathogenesis

The maintenance frequency approach represents hybrid strategy where initial intensive treatment (daily application for 3-6 months) establishes improvements, then reduces to maintenance schedule (2-3 times weekly or every other day) rather than complete discontinuation

It accomplishes this by playing a key role in the production of many neurotransmitters in your brain , including serotonin, GABA and dopamine