CrossRef Baseline and Longitudinal Metabolic Vulnerability Index and Risk of Incident Chronic Kidney Disease Among Adults With Dysglycemia Dan Chen, Jinsheng Mai, Ziliang Ye, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Yu Huang, Yiting Wu, Yiwei Zhang, Xianglian Cai, Xiaolong Liang, Xianhui Qin, Yuanyuan Zhang Journal of Renal Nutrition.2026;[Epub] CrossRef From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics Emmanuel Ifeanyi Obeagu Precision Medical Sciences.2026;[Epub] CrossRef The dysregulated unfolded protein response in diabetic kidney disease: mechanisms and crosstalk with cell death pathways Hao Zhang, Kaixiang Li, Jia Ma, Ling Ma, Muhammad Asad Farooq, Jing E Frontiers in Pharmacology.2026;[Epub] CrossRef Hsa-miR-5585-3p regulates the NLRP3 activation and the expression of cytokines through CHUK in a cellular model of diabetic kidney disease Jing Zeng, Xuexiang Qin, Jielian Wang, Cunyou Xiong, Xiaoyun Feng BMC Endocrine Disorders.2026;[Epub] CrossRef UbiquitinationRelated Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation Ting Dong, Miao Hu, Haibo Yu, Ling Zhou, Qing Qiao The FASEB Journal.2026;[Epub] CrossRef Association between 24-h proteinuria and phenotypic age acceleration in adults with preserved kidney function: a cross-sectional study Yiqi Su, Fangfang Xiang, Yi Fang, Xiaoqiang Ding, Wuhua Jiang International Urology and Nephrology.2026;[Epub] CrossRef Exosomes from diabetic perirenal adipose-derived MSCs promote inflammation and fibrosis in diabetic nephropathy via the miR-331-3p/TSC1/mTORC1 Axis Yumei Zhao, Hejia Yin, Hong Tan, Yan Zhao, Rou Shi, Ye Xing, Yang Li International Immunopharmacology.2026
Laboratory studies CBC: normal or nonspecific findings BMP: possible Na + , Cr Liver chemistries: AST and ALT Imaging: frequently performed in acute attacks to rule out differential diagnoses Abdominal imaging (x-ray or CT): Typically normal May show dilated bowel loops with air-fluid levels representing an ileus MRI or CT brain Typically normal May show white matter vasogenic edema affecting the posterior brain, consistent with posterior reversible encephalopathy syndrome (PRES) [9] Confirmatory studies First-line testing: spot urine sample for heme precursor levels Porphobilinogen (PBG): ( 20200 mg/L) -aminolevulinic acid (ALA): ( 10100 mg/L) Second-line testing Porphyrin levels: greatly increased in urine, normal to slightly increased in feces and plasma Erythrocyte porphobilinogen: decreased Enzyme activity measurement and DNA testing A 24-hour urine collection is not necessary for the diagnosis of an acute AIP attack and delays diagnosis
The remaining fat particles were digested with 0.2% collagenase (Gibco, Billings, MT, USA) in a water bath shaker at 37 C for 30 min, and the mixture was centrifuged at 1000 rpm for 5 min to remove undigested fat
178,525 FGF2 promotes angiogenesis and retinal fibrosis by stimulating vascular endothelial cell proliferation and inducing VEGF secretion
