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Morphologically, ferroptotic cells display a contracted mitochondrial outer membrane, denser membrane structure, and a lack of mitochondrial cristae, without apoptotic vesicles or nuclear fragmentation[18] (Fig

This creates a massive cytorheological gradient of free cytoplasmic norepinephrine, which is subsequently extruded into the synaptic cleft via transporter-mediated reverse transport (facilitated exchange diffusion) through NET (Solanki et al, 2014)

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Histologically, melatonin did not fully prevent immune cell accumulation in the lung parenchyma when Luzindole was present, however, the extent of infiltration remained markedly reduced compared with IL-33 alone ( Figures 2D, E )