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On the one hand, TME immunomodulation can trigger macrophage polarization from alternately activated macrophages M2 to classically activated macrophages M1, offering intertumoral H 2 O 2 for the Fenton reaction (Zanganeh et al., 2016), which effectively generates ROS and triggers lipid peroxidation (Yang and Stockwell, 2016

Xanthones (Figure 4A) are effective antioxidants with heterocyclic structures (Martnez et al

Absorption, distribution, metabolism, and excretion of US food and drug administration-approved antisense oligonucleotide drugs

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