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Avoid strenuous activities: Refrain from activities that may cause excessive sweating or friction on the treated area to prevent irritation or infection

In 1990, Broelsch et al., reported the first 20 series of LDLT in the USA [55]

However, heat shock stress during cryopreservation can compromise oocyte viability

In conclusion, we found that metformin may alleviate the pathological progression of OA primarily by activating Nrf2 signaling pathway, thereby confirming the promising potential of metformin as a treatment paradigm for OA