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355,356 The BBB not only allows highly selective permeability of substances entering and exiting through specialized structures (seal off adjacent BECs) but also dynamically regulates cerebral blood flow through the process of neurovascular coupling, maintaining homeostasis and neuronal function in the CNS

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So far, several approaches have been proposed including lifestyle and diet improvements, as well as food supplements (e.g., butyrate), prebiotics and probiotics and fecal microbial transplantation (FMT)