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Absorbance was read at 420 nm using a spectrophotometer (Polaris ), and results were interpolated using a standard curve, expressed in mol/L of saliva

Targeting key NAD + -consuming enzymes, glycolytic proteins, and components of the tricarboxylic acid cycle/electron transport chain (TCA/ETC), as well as markers of mitochondrial dynamics and signaling/transcription molecules/factors, revealed a metabolic dysfunction in CD4 + , but not CD8 + T cells of APP carriers, as compared to healthy individuals (Fig

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Numerous studies have shown that patients with CD exhibit dysbiosis, characterized by compositional shifts across the oral, duodenal, and fecal microbiota