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In the current study, APAP reduced the diversity of intestinal flora in mice, which was reduced through GC treatment, and hence, the liver restored its physiology upon application of GC

While ETC activity drives pro-ferroptotic ROS generation via electron leakage, it is also essential for anti-ferroptotic enzymes (e.g., DHODH and GPD2) that reduce mitochondrial coenzyme Q (CoQ) to ubiquinol (CoQH 2 ) (113115)

It remains unclear whether distinct death signals are activated sequentially, in parallel, or undergo context-dependent modulation at the single-cell or population level-particularly across different respiratory epithelial subtypes and immune cell populations under diverse stress conditions

Published online February 21, 2020 DOI: 22,014 View 322 Download 102 Web of Science 105 Crossref Abstract PDFPubReader ePub Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications