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The extent and nature of -syns conformational changes directly correlate with PD progression and symptom severity (So and Watts 2023

Subsequently, repair or degeneration occur, which depend on multiple factors such as the type and extent of damage, the immune system, the genetic susceptibility to disc degeneration, which is linked with age, the biomechanical (functional) condition that is created by the injury, and finally the type of treatment: conservative (disc loading) or operative (disc unloading)

Given the significant role of the brain tumor microenvironment in radiation response (Table 3), this would represent a key advancement upon current models

Int J Mol Sci 2020;21:868