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On the one hand, NAM levels might increase as a result of increased NAD + degradation through NAD + -consuming enzymes

The pathological features of PD, particularly iron accumulation, oxidative stress, and mitochondrial dysfunction, bear striking similarities to the hallmarks of ferroptosis

EMBO J 35:26862698 Kim DS, Challa S, Jones A, Kraus WL (2020) PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis