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Both FRDA fibroblast cell lines showed reduced expression levels of the mitochondrial subunits, NDUFS1 and SDHB compared to control, which could be explained by the Fe-S cluster deficit

Finally, cancer-associated fibroblasts (CAFs) can be activated by ROS and inflammation in the tumor microenvironment 173 and are also consistently implicated in tumor progression by supporting tumor growth and invasion through secretion of cytokines and extracellular matrix remodeling components 174