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These use the AdoB 12 (adenosylcobalamin) form of the vitamin

High blood pressure, atherogenic cholesterol particles, elevated blood sugar, smoking, chronic kidney disease, inflammation, inactivity, poor sleep, and genetic factors may accelerate vascular damage

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In a trial of patients with T2DM and BMI 27 kg/m2 or more receiving semaglutide injection for weight management, retinal disorders were reported by 6.9% of patients treated with semaglutide 2.4 mg/week, 6.2% of patients treated with semaglutide 1 mg/week, and 4.2% of patients treated with placebo