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These factors make it difficult for rodents to reach and sustain high blood alcohol levels, which in turn explains why they do not experience significant liver damage 141

It also upregulates the expression of the gastrointestinal barrier proteins ZO-1 and occludin in MPTP-treated mice, improves intestinal barrier function and gastrointestinal dysfunction, and consequently exerts a neuroprotective effect indirectly via the gut-brain axis ( Another study demonstrated that administration of neohesperidin, the primary active component of citrus fruits (25 and 50 mg/kg, administered for 24 days), significantly alleviated MPTP-induced damage to dopaminergic neurons in the substantia nigra-striatal pathway of PD mice, increased levels of striatal dopamine (DA) and its metabolite DOPAC, and improved motor dysfunction

Drug and Statistics (DAS) software (Version 3.0, Shanghai University of Traditional Chinese Medicine

It is important to note that we are not the only group to show that the type of anticoagulant used during sample collection impacts measurement of analytes within blood