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Various pathways, including pentose phosphate pathway (PPP) 21,22,23,24 , malic enzyme 25,26 , isocitrate dehydrogenase 27,28 and folate pathways 29,30 , have been reported to contribute significantly under different situations (for example, biosynthesis during proliferation, lipogenesis, redox defence and so on)

Song Q, Feng YB, Wang L, Shen J, Li Y, Fan C, et al

It should be noted, however, that symptomatic vitamin E deficiency in healthy individuals who consume diets low in vitamin E has never been reported (58, 59)